Introduction | History | How It Works
Uses | Typhoid Fever | Side Effects
Synthetic Production | U.S. and the West
In 1947, professor of plant pathology at the University of Illinois David Gottlieb isolated a strain of Streptomyces (a bacteria found in soil), from which Chloramphenicol was developed.
Chloramphenicol was introduced into clinical use in 1948.
Chloramphenicol was seen, upon its discovery, as a near-perfect drug.
• It could be given orally, and at home
• Because of it high pH, it is able to penetrate purulent material (material containing pus), and through cell membranes to parasites and into organs that other antibiotics could not reach