In 1722, Cooke moved to London hoping to earn his living as a writer, contributing articles to the daily papers, and seeking out patrons among the whigs. He dedicated almost all of his works to persons of nobility. He was a prolific poet, but he was most famous for his classical translations; his translation of Hesiod earned him the nickname "Hesiod Cooke." In some of his works, he attacked Pope and company, prompting Pope to ridicule Cooke in the Dunciad and Epistle to Dr. Arbuthnot. Cooke was also a playwright, selling his collection to Mrs. Oldfield, the actress, and after whose death it was purchased (1737) by Queen Caroline for £200. Cooke became increasingly indebted throughout his life, and he died destitute.