The Role of Chemistry in History

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Discovery and Synthesis

April 25th, 2008 · No Comments ·


Introduction to Testosterone Chemistry of Testosterone Historical Significance

Anabolic Steroids

The Future of Testosterone


Prehistory and Religious Doctrine

-Jewish Circumcision

-Egyptian Fertility Statues found in pyramids

The Middle Ages

-Human Castration

-Serendipitous Discovery that the Testes effect behavior, emotion and overall health

1849-Arnold Berthold

-experimentation of castration on chickens

1889-French Physiologist, Charles Edouard Brown-Sequard

“Rejuvenating therapy for the body and mind”

1918- Leo L. Stanley, resident physician of San Quentin State Prison in California

transplanted testicles removed from recently executed prisoners into inmates: some of whom claimed that they recovered sexual potency

1927- Fred C. Koch, University of Chicago’s Professor of Physiologic Chemistry

In 1927, Koch and his student, Lemuel McGee, derived 20mg of a substance from a supply of 40 pounds of buffalo testicles that, when administered to castrated roosters, pigs and rats, remasculinized them.

1934- Ernst Laquer

purified testosterone from bovine testicles

1935- Adolph Butenandt and Leopold Ruzicka

-funded by pharmaceuticals research labs in Germany and Switzerland respectively, joint synthesis

-the two share the 1939 Nobel Peace Prize

The early 1930s 1950s “The Golden Age of Steroid Chemistry”

Research proved that this newly synthesized compound — testosterone — was a potent multiplier of muscle, strength, and wellbeing.


Tags: Testosterone