The Role of Chemistry in History

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Cancer and THC

April 28th, 2008 · Comments Off on Cancer and THC ·

Introduction to THCHistory of THCTHC in the NewsCancer and THC

Effects of THC Chemistry of THC

cancer-and-thc.jpg

Connection with Cancer:

  • THC and Marijuana do not cause lung cancer, this is a common misconception because many people tie it in with tabacco products
  • THC is not a cure for cancer either, but it does help many people with the pain of chemotherapy
  • Although it is not a cure for cancer, there has been instances where THC as cut the growth of lung cancer by half. The study has only been done on mice at this point, but is in the process of injecting THC into humans.
  • Research as shown that THC can block the production of malformed cells that are the hallmark for Alzheimer’s Disease better then any other drug that is being prescribed now
  • It is believed that 4.5 million Americans suffer from Alzheimer’s Disease in America
  • Other investigations have shown that years of heavy marijuana use, four or more joints a week, can impair memory, decision-making and the ability to pay attention to more than one thing at a time.

THC is now being able to treat the following:

  1. As an antiemetic to control nausea and vomiting associated with cancer chemotherapy.
  2. As an antiemetic to control nausea and vomiting associated with the use of drugs for controlling the spread of the AIDS virus; without which patients could regurgitate the nausea inducing drugs before being properly absorbed by the body.
  3. To retard or reverse the weight reduction syndrome of AIDS.
  4. To control seizures in patients suffering from epilepsy.
  5. To reduce pressure within the eyes associated with glaucoma.
  6. To alleviate muscle spasms associated with multiple sclerosis.
  7. To alleviate pain and muscle spasms for paraplegics and quadriplegics. (Karl Harrison)

 

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Chemistry of THC

April 28th, 2008 · 8 Comments ·

Introduction to THCHistory of THCTHC in the NewsCancer and THC

Effects of THC Chemistry of THC

thc-skeletal.png

Structure of THC:

  • Boiling Point 200 degrees C
  • Chemical formula: C 21 H 30 O2
  • The structure of THC is classified by where the double bonds occur. The molecule is classified by delta and then a number
  • The molecule as two chiral carbons allowing for four stereo-isomers to form
  • The double bonds in the molecule lock the atoms in place creating cis and trans isomers
  • The place in which the double bond is causes one molecule of THC to be more potent then other.
  • The top ring contributes to the cannabinoid activity in the receptors
  • But the most important part of the molecule is the side chain, potency can be increased by adding more carbons on to it. It can be increased by 7 carbon chains
  • The orientation of the side chain on the lower part of the chain plays an important role on how the receptor receives the molecule
  • The configuration of the hydroxy group is critical to determining the potency
  • When the receptors receive the molecule, the exact line up of the bonds and side chains determine how “high” one will get when smoking or ingesting the molecule

 

http://upload.wikimedia.org/wikipedia/commons/7/77/Thc.pdb.gif

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Introduction to THC

April 28th, 2008 · 10 Comments ·

Introduction to THCHistory of THCTHC in the NewsCancer and THC

Effects of THC Chemistry of THC

Tetrahydrocannabinol (THC)

 

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Tetrahydrocannabinol (THC) is the active ingredient in Cannabis Sativa or Marijuana.

  • It is a mind altering drug, known as a hallucinogen but rarely ever causes hallusinations by itself.
  • Marijuana was used by drug companies to help decrease pain in the body in the early 1900’s,
  • By 1937 the drug was banned from the United States
  • But it was not widely known or used by the general public until the 1960’s.
  • There are over 200 different names for Marijuana, such as pot, weed, herb, Mary Jane, Gangster, Chronic ect.
  • Marijuana is usually smoked through a pipes or bongs
  • In recent years, a popular way of smoking weed is by emptying a cigar and packing it with Marijuana

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Industrial Development

April 28th, 2008 · Comments Off on Industrial Development ·

Introduction to ConcreteAnalysis of CaCO3 | Concrete Affects History | Industrial Development | Calcium Carbonate Accomplishments | Damage | History Affects CaCO3: Future of Concrete

Calcium Carbonate has shaped history by establishing a World-Wide Economic Industry 

  • The past half-decade saw a global expansion of 633 million tons.Š
    • Almost 70%, or 440 million tons of this comes from East Asia alone.
    • 76 million tons come from other Asian countries.
    • 7 million tons from Central and South America
    • 44 million tons from Africa/Middle East
    • 48 million tons from Europe
    • 20 million tons from North America.

 200639145445386.jpgA Chinese International Cement Industry Exhibition

Cement trade

  • The world cement trade has risen almost continuously over the past 35 years, advancing from 20 million tons in 1970, to 71 million tons by 1990, and to 155 million tons last year. 
  • Current cement consumption closely mirrors that of production, emphacizing the relatively low level of international cement trade volumes relative to world demand. (Good thing we won’t be running out of it anytime soon.)

Hawaii’s Volcanic Ash

The Hawaiian Islands have been coveted and industrialized for its supplies of volcanic ash. The ash is an important aggregate mixture with the CaCO3 limestone in certain mixtures. This has brough much wealth to the tiny state, and although the pulvurization of the islands has harmful environmental effects, the concrete industry gives it something else to export besides sugarcane.

Staple of Modern Construction

The versitility, strength, and overall availablility of Calcium Carbonate and other earthly compounds make concrete the most widely used building material all around the world. Take a look around you, and see just how much of where you live, work, and play is dictated by the use of concrete to suspend you, your car, and everything else. Truely, CaCO3 has had a profound effect on our world, our industries, and how we have come to know them today.

nsc-1712.jpg  paramount.jpg

(above, left: The New Rector Science Complex, under construction on the Dickinson College campus, using an internal concrete support structure, Carlisle, PA.) circ. 2007

(above, right: The Tallest Precast Concrete Building West of the Mississippi, The Paramount Building is Topped Off in San Francisco, CA. It was one of the first to employ methods that Dickinson is doing right now.) circ. 2001

Specific Industrial Uses of Calcium Carbonate

  • Additive to calcium supplement health tablets and anacids.
  • Additive to liquid products to create a paste, such as in toothpaste.
  • Ingredient in babies’ diapers to create its microporous film lining.
  • Pure CaCO3 can be marketed as blackboard/sidewalk chalk.
  • Used as a food additive in calcium shakes, soy milk, and baby formula.
  • MAKING POKER CHIPS!!! YAY FOR CACO3 GAMBLING!!!

http://www.cementchina.net/news/shownews.asp?id=1570

http://findarticles.com/p/articles/mi_m0NSY/is_6_24/ai_n16497840

www.dickinson.edu/…/august/images/NSC-1712.jpg

http://www.lehighsw.com/projects/proj.htm

http://en.wikipedia.org/wiki/Calcium_carbonate

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Concrete Affects History

April 28th, 2008 · Comments Off on Concrete Affects History ·

Introduction to ConcreteAnalysis of CaCO3 | Concrete Affects History | Industrial Development | Calcium Carbonate Accomplishments | Damage | History Affects CaCO3: Future of Concrete

  • Calcium Carbonate makes up approximately 4% of Earth’s crust, so it has been a part of history since the beginning of the beginning, contributing to the rise and fall of many ancient civilizations.

  • The earliest records of primitive concrete being made date back to 5600 BC in modern day Serbia, with a hut made of a red lime, sand, and gravel mixture.       (This was before even the Sumerian Civilization began in Mesopotamia.)

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  • The Ancient Egyptians established their architecture using a lime and gypsum cement. The stone covering of the Great Pyramids at Giza that tourists see today is the remaining limestone shell, which is of course, CALCIUM CARBONATE!!

    300px-all_gizah_pyramids.jpg(CaCO3 remains as a reminder of the great power of Ancient Egypt during 3000 BC.)

 

  • The Romans have Calcium Carbonate to thank for their Empire (approx 700 BC-100 BC), because their great cites were supplied with fresh water from concrete aquaducts, made from a quicklime, pozzolanic ash, and pumice mixture, along with some additives like Horse hair and blood. 

(A Roman aquaduct remains in France.) pont_du_gard.jpg

 

  • From the 1850’s on, after Joeseph Aspdin patented his Portland Cement, the perfected mixture found its way to making roads, bridges, tunnels and dams in all areas of the world. These structures revolutionized many countries as they could now navigate to new areas and trade with areas that before were unreachable.

  • This made the transportation of people and goods more efficient, splendidly intensifying the economies of both Britain and the United States.

  • Paved roads, whether it comes from concrete or asphalt were extremely important for the distribution of the population throughout the United States, and the development of the Western States.

 highway2.jpg(Even if the road is not made of cement, chances are that the structures suspending it are. Yay CaCO3!!)

http://www.kuhlman-corp.com/HistoryCon.html

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Analysis of CaCO3

April 28th, 2008 · 3 Comments ·

Introduction to Concrete | Analysis of CaCO3 | Concrete Affects History | Industrial Development | Calcium Carbonate Accomplishments | Damage | History Affects CaCO3: Future of Concrete

  • The properites and abilities of concrete are derived from the molecular stucture of CaCO3 and of other molecules like it.

 

mco3pol.png 

The Carbonate Molecule CO3: A Trigonal Planer Arrangement

 

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3D Sketch of two CO3 Molecules interacting with Calcium Ions: The CaCO3 Molecule. They form a Semi-“pleated sheet” crystalline structure.

 

 

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With the introduction of water (H2O) molecules, the structure of the CaCO3 molecules change. The molecules form a permeable “cage” that can move as liquid, but solidify as rock under heat and pressure.

  • When the calcium carbonates first come into contact with water, a reaction occurs in which calcium ions are formed and the water molecules are broken down to form hydroxide ions. It is this bond breaking that produces heat. Calcium hydroxide is not very soluble so it is soon saturated and forms a solid.
  • As long as water is in contact with the cement, these reactions continue but they get slower and slower, and can take several years to reach full strength.
  •  As the solid is formed, however, there is less and less space between the grains of aggregate and carbonate for the water to move around and reach un-reacted cement. This means that the reaction will slow down as the pores between the aggregate get smaller.

 (until you become this guy!!) img_0200.jpg

http://chemistry.suite101.com/article.cfm/the_chemistry_of_concrete

http://www1.elsevier.com/homepage/saa/eccc3/paper54/paper54.html

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THC in the News

April 28th, 2008 · 1 Comment ·

Introduction to THCHistory of THCTHC in the NewsCancer and THC

Effects of THC

800px-map-of-us-state-cannabis-lawssvg.png

Above is a map of the United States, the highlighted states are states that have made new laws for Marijuana

  • ██ State with legal medical cannabis.

    ██ State with decriminalized cannabis possession laws.

    ██ State with both medical and decriminalization laws.

  • The gray states are states that completely outlaw any use of Marijuana

Below is a world map that displays countries individual laws pertaining to the use of Marijuana:

worldmap1.jpg

  • Dark Blue: Legal/Essentially Legal
  • Light Blue: Decriminalization
  • Orange: Illegal, but mostly unenforced
  • Red: Confirmed Illegal
  • Pink: Probably varies by region
  • Gray: No information

This map above show that the use of THC in Marijuana, is not just an American debate, but a world wide one. The rules vary for each country, depending on their tolerance of the drug.
THC on 60 minutes and the stores in California

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Introduction to Concrete

April 28th, 2008 · 10 Comments ·

Introduction to ConcreteAnalysis of CaCO3 | Concrete Affects History | Industrial Development | Calcium Carbonate Accomplishments | Damage | History Affects CaCO3: Future of Concrete

 barrow.jpg    ——————->      washingtonmonument-001.jpg

 In the world of construction, one material is used above all others: concrete. Concrete is absolutely indespensible in modern society’s fascination with new roads, buildings and other constructions. One industry expert has gone as far as to say that now “concrete IS chemistry.” This is due to the increasing development of admixtures which chemically affect certain properties of concrete.   -Simon Davies The Chemistry of Concrete

  • The three basic ingredients of concrete are aggregate, cement, water. Cement is the fixture that binds the ingredients together, water gives the concrete viscocity in order to be molded and react with the ingredients, and the aggregates are what adds bulk to the concrete, but are not involved in the chemical processes.

  •  Cement, the building block of concrete is composed of innumerable, natural occuring elements, earthly compounds, and alkali metals: among them is Calcuim Carbonate. The cement mixture is created by crushing up clay and limestone together and roasting it in a kiln. 

    cem_ball_mill.jpg

     

    The formed powder typically has a similar chemistry to the following:

    75% Di, Tri- calcium silicate

    10% Tetracalcium aluminoferrite

    10% Tricalcium aluminate

    10% Gypsum or Hydrated calcium suphate

    • Calcium Carbonate serves as a general term referring to the limestone base that is quarried from mines in order to complete the mixture, and is especially important. 
    • Some other common materials found in finished Concrete are chalks, marbles, oyster shell, shale, clay, slags, fly ash, bauxite, alumina process waste, and granite, silica sand, iron ores, blast furnace flue dusts, pyrite clinker, and mill scale. CaCO3 is present in most.   -Charles Kubach, Mineral Processing Engineer, Sepor Inc.

http://chemistry.suite101.com/article.cfm/the_chemistry_of_concrete

http://www.mine-engineer.com/mining/cement.htm

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Effects of THC

April 28th, 2008 · 9 Comments ·

Introduction to THCHistory of THCTHC in the NewsCancer and THC

Effects of THC Chemistry of THC

Effects:

  • Marijuana’s effect on the user depends on the strength or potency of the THC it contains. THC potency has increased since the 1970s but has been about the same since the mid-1980s. The strength of the drug is measured by the average amount of THC in test samples.
  • Most ordinary marijuana contains an average of 3% of THC
  • The more THC in the Marijuana the greater the effect of the brain will be
  • Within a few minutes of inhaling marijuana smoke, the user will likely feel, along with intoxication, a dry mouth, rapid heartbeat, some loss of coordination and poor sense of balance, and slower reaction time. Blood vessels in the eye expand, so the user’s eyes look red
  • The feeling of being “high” lasts for 2 to 3 hours and then makes the smoker tired and sometimes extremely hungry. This is known in slang terms as the “munchies”

How it works in the Body:

  • Marijuana can be inhaled or ingested into the body by either smoking or eating, some common ways to eat it is to make “magic” brownies or mix it with peanut butter and make a sandwich
  • The THC from the Marijuana goes to the brain and stays in the Synapse Clef until a special receiver, known as the Cannabinoid recpetor, receives the THC and creates the feeling of being high
  • Dopamine, the chemical in the brain that sends a message of feeling good to the body, is released.
  • thc-in-the-brain.jpg

  • Dopamine production is not increased nor decreased when using THC. This quality in itself make is one of the major reasons that Marijuana is not an addictive

Staying in the Body

  • THC is abosorbed by fatty tissue, for less frequent users THC can be traced in the body by a simple urine test for several days
  • For those chronic or heavy smokers, THC can be traced in the body for up to several weeks
  • People have now designed special drinks and concoctions to try and beat a drug test.

detox.jpg

  • These drinks can cost anywhere from $24 to $124 and they all are said to work for a simple urine test, but is not guaranteed for a blood test.
  • Most kits are designed to be taken over a three week time period for best results
  • These Kits include ingredients such as:
    • Herbs such as milk thistle, barberry, dandelion or schizandra – traditionally used to ‘detoxify’ the liver and aid normal liver function
    • Digestive aids such as ginger, globe artichoke and peppermint for treating indigestion
    • Laxatives like fennel, psyllium and senna
    • Diuretics like birch, dandelion, golden rod and spiny restharrow – these are supposed to increase bowel movements and urine elimination.
  • Scientist say that taking these drinks and pills is harmful to the body
  • Many believe that these so called “detox-kits” promote body abuse because you are able to find a quick fix in a bottle.

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Chloramphenicol

April 28th, 2008 · Comments Off on Chloramphenicol ·

Introduction | History | How It Works

Uses | Typhoid Fever | Side Effects

Synthetic Production | U.S. and the West

References

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